recombinant gzma (MedChemExpress)
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MedChemExpress
recombinant gzma
Recombinant Gzma, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+gzma/GZMA%2FGranzyme+A%2C+Mouse/pmc13198314-66-0-3
Average 94 stars, based on 1 article reviews
Recombinant Gzma, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+gzma/GZMA%2FGranzyme+A%2C+Mouse/pmc13198314-66-0-3
Average 94 stars, based on 1 article reviews
recombinant gzma - by Bioz Stars,
2026-10
94/100 stars
Images
1) Product Images from "Spleen-targeted neoantigen mRNA vaccine induces ISG15 + CD8 + T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma"
Article Title: Spleen-targeted neoantigen mRNA vaccine induces ISG15 + CD8 + T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma
Journal: Cell Reports Medicine
doi: 10.1016/j.xcrm.2026.102754
Figure Legend Snippet: GZMA-F2R interaction mediates STNvac efficacy through T cell activation (A) Bubble plot showing ligand-receptor pairs between ISG15 + CD8 + T cells and APCs (B cells, CD4 + T cells, and DCs). (B) Violin plots showing F2R expression across T cell subsets and GZMA expression in APCs. (C and D) Therapeutic evaluation of STNvac co-administration with F2R antagonist (F2RA, SCH79797 ) ( n = 7 mice per group). (C) Bioluminescence images showing tumor burden in orthotopic HCC-bearing mice under the indicated treatments. (D) Survival curves of mice in different groups. (E and F) Multicolor immunofluorescence staining of intratumoral Ki67 + CD69 + ISG15 + CD8 + T cells. (E) Representative images. Scale bars, 20 μm. (F) Quantitative analysis of positive cell density in five randomly selected areas per tumor section. (G and H) Activation of human HCC TILs through the GZMA-F2R interaction. (G) Schematic illustration of the treatment schedule. (H) Quantitative analysis of 41BB + CD3 + CD8 + T cells after 24 h of GZMA stimulation ( n = 2 biological replicates, each analyzed in triplicate). Statistics: one-way ANOVA for (F) and (H); log rank (Mantel-Cox) test for (D). Mean ± SD. Significance levels: ∗p < 0.05, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. See also and .
Techniques Used: Activation Assay, Expressing, Multicolor Immunofluorescence Staining
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Recombinant:Article Title: Granzyme K + CD8 + T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps Article Snippet: .. Cells were stimulated with 100 ng/ml of human recombinant GZMK (ProSpec, Ness-Ziona, Israel), 100 ng/ml of human Article Title: Spleen-targeted neoantigen mRNA vaccine induces ISG15 + CD8 + T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma. Article Snippet: Flow cytometric data were acquired on a BD FACSVerse and analyzed using FlowJo software. .. Flow cytometry of human HCC TILs To evaluate the impact of the GZMA-F2R signaling on CD8 + TIL activation, the in vitro-expanded TILs were seeded in 24-well plates, pre-treated with the F2R antagonist SCH79797 (MCE, 5 μM), and subsequently stimulated with Article Title: Spleen-targeted neoantigen mRNA vaccine induces ISG15 + CD8 + T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma Article Snippet: SCH79797 (F2R antagonist, F2RA) , MCE , Cat#HY-14994. .. Control:Article Title: Granzyme K + CD8 + T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps Article Snippet: .. Cells were stimulated with 100 ng/ml of human recombinant GZMK (ProSpec, Ness-Ziona, Israel), 100 ng/ml of human Flow Cytometry:Article Title: Spleen-targeted neoantigen mRNA vaccine induces ISG15 + CD8 + T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma. Article Snippet: Flow cytometric data were acquired on a BD FACSVerse and analyzed using FlowJo software. .. Flow cytometry of human HCC TILs To evaluate the impact of the GZMA-F2R signaling on CD8 + TIL activation, the in vitro-expanded TILs were seeded in 24-well plates, pre-treated with the F2R antagonist SCH79797 (MCE, 5 μM), and subsequently stimulated with Activation Assay:Article Title: Spleen-targeted neoantigen mRNA vaccine induces ISG15 + CD8 + T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma. Article Snippet: Flow cytometric data were acquired on a BD FACSVerse and analyzed using FlowJo software. .. Flow cytometry of human HCC TILs To evaluate the impact of the GZMA-F2R signaling on CD8 + TIL activation, the in vitro-expanded TILs were seeded in 24-well plates, pre-treated with the F2R antagonist SCH79797 (MCE, 5 μM), and subsequently stimulated with |